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In a study to identify the impact of different types of procedures for lung transplantation and the development of complications after transplantation, an international consortium of researchers led by surgeons at Baylor College of Medicine found that the off-pump approach results in a significant reduction in primary graft dysfunction, a serious complication that occurs when the new lung develops inflammation within the first three days of transplantation. Their findings were published recently in the Journal of Thoracic and Cardiovascular Surgery.

The off-pump approach occurs when the lung is removed from the recipient and their own heart and opposite lung can sustain them while the surgeon transplants the new lung, according to Dr. Gabriel Loor, associate professor in the Michael E. DeBakey Department of Surgery at Baylor and first author of the paper. However, not all patients qualify for an off-pump approach, and the study found that in those cases, the use of an extracorporeal membrane oxygenation (ECMO) machine leads to better outcomes compared to cardiopulmonary bypass.

“While lung transplantation saves the lives of thousands of patients worldwide every year, augmentin tm 625mg there continues to be room for improvement in the outcomes following transplantation,” said Loor, who is surgical director of the Lung Transplant Program at Baylor St. Luke’s Medical Center.

Loor and colleagues developed the consortium to answer the question of how to improve short-term outcomes of lung transplantation by choosing the appropriate mode of support.

In this study, they analyzed 852 transplants performed between January 2016 and March 2020 and found that 12.1% of the off-pump transplants resulted in severe primary graft dysfunction whereas 28.9% of ECMO and 42.7% of cardiopulmonary bypass transplants resulted in severe primary graft dysfunction.

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